Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581523 | 0.70 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL9752488 | 0.70 | MAPT (0.37) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL19229363 | 0.68 | KDM4E (0.38) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL26168101 | 0.67 | MAPT (0.34) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL1105676 | 0.66 | CYP2A6 (0.42) | ALDH1A1KDM4EMAPTTDP1KMT2A | |
| SCHEMBL9752517 | 0.66 | PTPN1 (0.35) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL22427835 | 0.66 | MAPT (0.33) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL19233625 | 0.66 | MAPT (0.33) | ALDH1A1KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL20187380 | 0.63 | EGFR (0.40) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL9752559 | 0.63 | HTT (0.32) | ALDH1A1KDM4EMAPTHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010664-A1 | PYRIDAZINO[4,5-b]INDOLIZINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-07-25 | — | — | WO | disclosed |