Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752932 | 1.00 | PTGS2 (0.34) | PTGS2PGRHTR6MAPK14EGFR | |
| SCHEMBL9753721 | 0.91 | PTGS2 (0.32) | PTGS2PGRMAPK14EGFRADORA2A | |
| SCHEMBL9753724 | 0.91 | PTGS2 (0.32) | PTGS2PGRMAPK14EGFRADORA2A | |
| SCHEMBL9753040 | 0.90 | PTGS2 (0.36) | PTGS2PGRHTR6MAPK14EGFR | |
| SCHEMBL9753157 | 0.85 | MAPK14 (0.41) | PTGS2MAPK14EGFRADORA2AADORA1 | |
| SCHEMBL9753160 | 0.85 | MAPK14 (0.41) | PTGS2MAPK14EGFRADORA2AADORA1 | |
| SCHEMBL9752975 | 0.82 | TP53 (0.34) | MAPK14SPR | |
| SCHEMBL9752977 | 0.82 | TP53 (0.34) | MAPK14SPR | |
| SCHEMBL9753124 | 0.82 | EGFR (0.38) | EGFRADORA2AADORA1 | |
| SCHEMBL9753122 | 0.82 | EGFR (0.38) | EGFRADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |