Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752975 | 1.00 | TP53 (0.34) | TP53HSD11B1MAPK14MAPK13MAPK12 | |
| SCHEMBL9753497 | 0.90 | MAPK14 (0.31) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9753499 | 0.90 | MAPK14 (0.31) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9753400 | 0.90 | TP53 (0.36) | TP53HSD11B1MAPK14MAPK13MAPK12 | |
| SCHEMBL9753160 | 0.83 | MAPK14 (0.41) | MAPK14 | |
| SCHEMBL9753157 | 0.83 | MAPK14 (0.41) | MAPK14 | |
| SCHEMBL9752930 | 0.82 | PTGS2 (0.34) | MAPK14SPR | |
| SCHEMBL9752932 | 0.82 | PTGS2 (0.34) | MAPK14SPR | |
| SCHEMBL9753670 | 0.80 | HMGCR (0.34) | — | |
| SCHEMBL9753663 | 0.80 | HMGCR (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |