Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753354 | 0.90 | PTGS2 (0.34) | PTGS2EGFRPGRKDRMAPK14 | |
| SCHEMBL9752932 | 0.90 | PTGS2 (0.34) | PTGS2EGFRPGRKDRMAPK14 | |
| SCHEMBL9752930 | 0.90 | PTGS2 (0.34) | PTGS2EGFRPGRKDRMAPK14 | |
| SCHEMBL9753321 | 0.84 | MAPK14 (0.44) | PTGS2EGFRMAPK14PTGS1ADORA2A | |
| SCHEMBL27438905 | 0.82 | RORC (0.38) | EGFRPGRKDRTGFBR1TGFBR2 | |
| SCHEMBL9753400 | 0.80 | TP53 (0.36) | EGFRMAPK14ADORA2AADORA1SPR | |
| SCHEMBL9753002 | 0.80 | TGFBR1 (0.36) | PTGS2EGFRPGRKDRMAPK14 | |
| SCHEMBL9753063 | 0.80 | EGFR (0.39) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9753724 | 0.80 | PTGS2 (0.32) | PTGS2EGFRPGRMAPK14ADORA2A | |
| SCHEMBL9753721 | 0.80 | PTGS2 (0.32) | PTGS2EGFRPGRMAPK14ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |