Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22779182 | 0.89 | — | — | |
| SCHEMBL6847340 | 0.83 | HTR1A (0.39) | TDP1CYP1A2HTR1APAOXHTT | |
| Hydrochloric Acid SCHEMBL22557794 | 0.81 | HTT (0.39) | TDP1CYP1A2HTR1APAOXSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL22557824 | 0.81 | HTT (0.39) | TDP1CYP1A2HTR1APAOXSMN1; SMN2 | |
| SCHEMBL10850124 | 0.79 | ALDH1A1 (0.43) | TDP1CYP1A2HTR1APAOXTP53 | |
| SCHEMBL3910470 | 0.77 | ALDH1A1 (0.33) | CYP1A2MAPTSMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL9596546 | 0.77 | CYP1A2 (0.44) | TDP1CYP1A2HTR1AMAPTPAOX | |
| SCHEMBL11842952 | 0.76 | KMT2A (0.35) | TDP1CYP1A2HTR1AMAPTPAOX | |
| SCHEMBL21590286 | 0.75 | NPC1 (0.48) | CYP1A2MAPTSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL10852322 | 0.75 | DGKA (0.44) | TDP1MAPTPAOXL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009029-A1 | THERAPEUTICALLY ACTIVE CHLORO SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE | Aktiebolaget Hässle (SE) | 1991-06-27 | — | — | WO | disclosed |
| US-4965269-A | INHIBIT GASTRIC ACID SECRETION | AB HASSLE (SE) | 1990-10-23 | — | — | US | disclosed |