Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753170 | 0.82 | MAPK14 (0.44) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL27348767 | 0.81 | DHODH (0.47) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753281 | 0.80 | MAPK14 (0.44) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9752940 | 0.79 | MAPK14 (0.43) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9752979 | 0.77 | KDM4E (0.51) | EGFRADORA3SLC34A1 | |
| SCHEMBL9753675 | 0.76 | MAPK14 (0.41) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753678 | 0.76 | MAPK14 (0.41) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL3825789 | 0.75 | MAPK14 (0.47) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9752933 | 0.72 | GCGR (0.54) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL3194040 | 0.70 | EGFR (0.53) | MAPK14EGFRRAF1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |