Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | SLC34A1 | Q06495 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753402 | 0.79 | MAPK14 (0.46) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753398 | 0.78 | MAPK14 (0.43) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753170 | 0.77 | MAPK14 (0.44) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753641 | 0.76 | LMNA (0.42) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753659 | 0.74 | MAPK14 (0.40) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753655 | 0.74 | MAPK14 (0.40) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL9753303 | 0.70 | PDE4D (0.57) | ADORA3PTGS2 | |
| SCHEMBL3825789 | 0.69 | MAPK14 (0.47) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL10500565 | 0.67 | MAPK14 (0.61) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL14810787 | 0.67 | CYP11B2 (0.47) | MAPK14EGFRRAF1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |