Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ATP4A | P20648 | 4/20 | 0.37 |
| ▸ | ATP4B | P51164 | 4/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8607290 | 0.86 | ALDH1A1 (0.40) | ALDH1A1GAAATP4AATP4BPTGS1 | |
| SCHEMBL8608835 | 0.84 | SMN1; SMN2 (0.48) | ALDH1A1GAAPTGS1PTGS2CYP1A2 | |
| SCHEMBL9923895 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAAPTGS1PTGS2CYP1A2 | |
| SCHEMBL6351785 | 0.79 | CYP3A4 (0.49) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9753914 | 0.78 | SMN1; SMN2 (0.38) | ALDH1A1GAAATP4AATP4BCYP1A2 | |
| SCHEMBL7853457 | 0.72 | ATP4A (0.61) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8608772 | 0.71 | SMN1; SMN2 (0.49) | ALDH1A1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL9081296 | 0.70 | KMT2A (0.46) | CYP3A4MAPTHPGDSMN1; SMN2HTT | |
| SCHEMBL8352177 | 0.69 | ALDH1A1 (0.68) | ALDH1A1GAAPTGS1PTGS2CYP1A2 | |
| SCHEMBL10751414 | 0.65 | CYP1A2 (0.47) | ALDH1A1ATP4AATP4BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |