Sugi Predict

Sugi Predict / Compounds / SCHEMBL8352177

SCHEMBL8352177

SCHEMBL8352177

Cc1c(C(=O)O)nc2ccccn12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.68
▸ GAA P10253 2/20 0.68
▸ PTGS1 P23219 3/20 0.66
▸ PTGS2 P35354 3/20 0.66
▸ KMT2A Q03164 3/20 0.53
▸ KDM4E B2RXH2 6/20 0.51
▸ THRB P10828 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ NPSR1 Q6W5P4 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.49
▸ MAPT P10636 2/20 0.47
▸ GLA P06280 1/20 0.47
▸ ATM Q13315 1/20 0.47
▸ RXFP1 Q9HBX9 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ TOP2A P11388 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20100081 0.86 ALDH1A1 (0.68) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL15924279 0.85 ALDH1A1 (0.70) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL20100079 0.82 ALDH1A1 (0.67) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL286358 0.82 ALDH1A1 (0.71) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL22817546 0.81 ALDH1A1 (0.65) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL9923875 0.81 ALDH1A1 (1.00) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL8707940 0.81 PTGS1 (0.68) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL28841197 0.80 PTGS1 (0.62) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL2505190 0.80 PTGS1 (0.62) ALDH1A1GAAPTGS1PTGS2KMT2A
SCHEMBL872190 0.80 PTGS1 (0.68) ALDH1A1GAAPTGS1PTGS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583849-B2 KCNT1 inhibitors and methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2026-03-24 — — US disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
EP-4692069-A2 KCNT1 INHIBITORS AND METHODS OF USE Praxis Precision Medicines, Inc. (US) 2026-02-11 — — EP disclosed
EP-4110317-B1 KCNT1 INHIBITORS AND METHODS OF USE PRAXIS PREC MEDICINES INC (US) 2025-11-19 — — EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
CN-115073454-B Imidazo pyridine-2-oxazoline compound and preparation method and application thereof 贵州大学 2024-03-08 — — CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20230167102-A1 KCNT1 INHIBITORS AND METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2023-06-01 — — US disclosed
US-20230167102-A1 KCNT1 INHIBITORS AND METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2023-06-01 — — US disclosed
US-9067935-B2 Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2015-06-30 — — US disclosed
US-9067935-B2 Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2015-06-30 — — US disclosed
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2014-03-27 — — US disclosed
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2014-03-27 — — US disclosed
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2014-03-27 — — US disclosed
US-8618150-B2 Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2013-12-31 — — US disclosed
US-20120149699-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2012-06-14 — — US disclosed
US-20120149699-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2012-06-14 — — US disclosed
WO-2012078994-A1 IMIDAZO [1, 2-A] PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2012-06-14 — — WO disclosed
WO-2003006471-A1 HETEROARYL SUBSTITUTED FUSED BICYCLIC HETEROARYL COMPOUNDS AS GABAA RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 2003-01-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583849-B2 KCNT1 inhibitors and methods of use KCNT1, SCN1A, KCNT2 ALDH1A1 1236/4885GAA 2046/4885PTGS1 1034/4885
US-20230167102-A1 KCNT1 INHIBITORS AND METHODS OF USE KCNT1, KCNT2, KCNQ2 ALDH1A1 2052/4885GAA 586/4885PTGS1 1858/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH ALDH1A1 587/4885GAA 290/4885PTGS1 936/4885
US-20120149699-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPV1, TRPM2 ALDH1A1 2230/4885GAA 2699/4885PTGS1 347/4885
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPV1, TRPM2 ALDH1A1 2230/4885GAA 2699/4885PTGS1 347/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP ALDH1A1 312/4885GAA 94/4885PTGS1 1220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.