SCHEMBL9754474

SCHEMBL9754474

COc1nc(OC)nc(Oc2cccc(-c3ccc(Cl)cc3)c2C(=O)O)n1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C19 P33261 1/20 0.44
ATM Q13315 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CYP3A4 P08684 1/20 0.43
CYP2C8 P10632 1/20 0.43
DHODH Q02127 1/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9053287 0.87 CYP2C9 (0.40) CYP2C9CYP1A2CYP2C19ATMNPSR1
SCHEMBL25285914 0.84 CA12 (0.61) CYP2C9ATMCYP3A4CYP2C8DHODH
SCHEMBL9754628 0.84 DHODH (0.43) CYP2C9CYP1A2CYP2C19ATMNPSR1
SCHEMBL9754476 0.81 ALDH1A1 (0.41) NPSR1CA12CA1CA2CA7
SCHEMBL9682580 0.81 CA12 (0.49) NPSR1CA12CA1CA2CA7
SCHEMBL9215334 0.79 CYP1A2 (0.52) CYP2C9CYP1A2CYP2C19ATMNPSR1
SCHEMBL9129900 0.77 LMNA (0.46) CYP2C9CYP1A2CYP2C19NPSR1CYP3A4
SCHEMBL9046270 0.77 CA12 (0.41) DHODHCA12CA1CA2CA7
SCHEMBL9754622 0.76 CYP1A2 (0.47) CYP2C9CYP1A2CYP2C19NPSR1CYP3A4
SCHEMBL9128119 0.76 LMNA (0.45) CYP2C9CYP1A2CYP2C19NPSR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991013065-A1 6-ARYL-2-SUBSTITUTED BENZOIC ACID HERBICIDES FMC CORPORATION (US) 1991-09-05 WO disclosed