Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15147253 | 0.80 | CHRNA1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL4438266 | 0.79 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL11467643 | 0.78 | OPRL1 (0.47) | CYP1A2POLBOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL4442672 | 0.77 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL6263031 | 0.75 | GRIN2B (0.30) | GRIN2B | |
| SCHEMBL7824744 | 0.75 | OPRM1 (0.53) | POLBSLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6139565 | 0.75 | L3MBTL1 (0.40) | ALDH1A1POLBGRIN2B | |
| SCHEMBL9542156 | 0.72 | CHRNA1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL31158958 | 0.72 | POLB (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL18019019 | 0.72 | CHRNA1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991013616-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-09-19 | — | — | WO | disclosed |
| EP-0403487-A4 | NOVEL HMG-COA REDUCTASE INHIBITORS | — | 1991-06-05 | — | — | EP | disclosed |
| US-4996234-A | Anticholesterol agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0403487-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-12-27 | — | — | EP | disclosed |
| US-4900754-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORP. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4863957-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| WO-1989005639-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-06-29 | — | — | WO | disclosed |