Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | ST6GAL1 | P15907 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845632 | 0.87 | LMNA (0.54) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL24127869 | 0.81 | LMNA (0.57) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9755548 | 0.80 | LMNA (0.72) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL4384095 | 0.75 | LMNA (0.49) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL23907066 | 0.73 | LMNA (0.55) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL24117282 | 0.72 | LMNA (0.51) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL23254273 | 0.72 | LMNA (0.69) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10024081 | 0.72 | LMNA (0.56) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10024084 | 0.72 | LMNA (0.56) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18231346 | 0.71 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019727-A1 | 5'-HYDROGENPHOSPHONATES AND 5'-METHYLPHOSPHONATES OF SUGAR MODIFIED NUCLEOSIDES, COMPOSITIONS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-12-26 | — | — | WO | disclosed |