Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.53 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | RHOC | P08134 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.52 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750867 | 0.83 | HMGCR (0.66) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9756757 | 0.82 | HMGCR (0.56) | HMGCR | |
| SCHEMBL9750901 | 0.80 | HMGCR (0.53) | HMGCR | |
| SCHEMBL14605736 | 0.80 | HMGCR (0.69) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL5240504 | 0.78 | HMGCR (0.86) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL12553314 | 0.78 | HMGCR (0.86) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9750940 | 0.77 | HMGCR (0.79) | HMGCR | |
| SCHEMBL9518621 | 0.76 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9756770 | 0.74 | HMGCR (0.54) | HMGCRABCB11ABCC3 | |
| SCHEMBL14549241 | 0.74 | HMGCR (0.77) | HMGCRABCB11SLCO1B1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992462-A | Inhibitor of HMG-CoA reductase | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |
| CN-1030075-A | The pyroles that replaces | BAYER AG (DE) | 1989-01-04 | — | — | CN | disclosed |