SCHEMBL9756794

SCHEMBL9756794

O=S(=O)(c1ccc(-c2ccccc2Cl)cc1Br)c1ccc(-c2ccccc2Cl)cc1Br

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.42
PTGS2 P35354 4/20 0.40
PTGS1 P23219 3/20 0.40
TNKS2 Q9H2K2 1/20 0.39
PTGES2 Q9H7Z7 1/20 0.39
BACE1 P56817 1/20 0.39
TRPA1 O75762 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
TYK2 P29597 1/20 0.38
JAK3 P52333 1/20 0.38
KAT6A Q92794 1/20 0.37
AR P10275 1/20 0.37
PDK2 Q15119 1/20 0.37
PGR P06401 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9756797 0.75 TSHR (0.42) PTGS2PTGS1CA1CA2
SCHEMBL458252 0.73 CYP2A6 (0.42) CYP2A6TNKS2BACE1TRPA1JAK2
SCHEMBL9491076 0.71 TNKS2 (0.47) CYP2A6PTGS2TNKS2KAT6APDK2
SCHEMBL5028730 0.71 CYP2A6 (0.58) CYP2A6PTGS2PTGS1CA1CA2
SCHEMBL3446890 0.70 PTPN1 (0.50)
SCHEMBL14956040 0.70 PTPRC (0.47) CYP2A6CA1CA2
SCHEMBL21662218 0.69 CYP2A6 (0.54) CYP2A6BACE1TRPA1JAK2JAK1
SCHEMBL28820907 0.68 PTGS2 (0.73) CYP2A6PTGS2PTGS1CA1CA2
SCHEMBL3444899 0.68 HSD11B1 (0.42) PTGS2PTGS1
SCHEMBL9459891 0.68 MIF (0.47) JAK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5037954-A Method to recover liquified poly(arylene sulfide) with separation agent PHILLIPS PETROLEUM COMPANY (US) 1991-08-06 US disclosed
EP-0436120-A2 Method to recover poly(arylene sulfide)s PHILLIPS PETROLEUM COMPANY (US) 1991-07-10 EP disclosed