Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26107968 | 0.87 | TBXAS1 (0.56) | TBXAS1BCL2L1GPR35HDAC1MEN1 | |
| SCHEMBL17486405 | 0.85 | CLK1 (0.61) | TBXAS1HDAC1KMT2ACLK1DYRK1A | |
| SCHEMBL2626934 | 0.85 | TBXAS1 (0.57) | TBXAS1BCL2L1GPR35HDAC1MEN1 | |
| SCHEMBL30474713 | 0.84 | MEN1 (0.49) | TBXAS1HDAC1MEN1KMT2ACLK1 | |
| SCHEMBL10951469 | 0.84 | MEN1 (0.49) | TBXAS1HDAC1MEN1KMT2ACLK1 | |
| SCHEMBL17173220 | 0.83 | TBXAS1 (0.56) | TBXAS1BCL2L1GPR35HDAC1MEN1 | |
| SCHEMBL2895956 | 0.83 | KMT2A (0.61) | TBXAS1BCL2L1GPR35HDAC1MEN1 | |
| SCHEMBL10374158 | 0.80 | CA2 (0.56) | TBXAS1BCL2L1GPR35HDAC1MEN1 | |
| SCHEMBL17433719 | 0.79 | STING1 (0.42) | TBXAS1HDAC1MEN1KMT2ACLK1 | |
| SCHEMBL9176841 | 0.79 | CYP4F2 (0.51) | HDAC1CLK1DYRK1ADYRK1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0050957-B1 | HETEROCYCLIC THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1984-08-22 | — | — | EP | disclosed |
| EP-0050957-A1 | Heterocyclic thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-05-05 | — | — | EP | disclosed |