Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757236 | 0.90 | GPBAR1 (0.53) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL9757076 | 0.87 | ALOX5 (0.59) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL7716747 | 0.82 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9757054 | 0.79 | PDE10A (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL9757124 | 0.79 | ALOX5 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL6092293 | 0.79 | CYSLTR1 (0.57) | CYSLTR1GPBAR1CYSLTR2ALOX5KDM4E | |
| SCHEMBL6088393 | 0.78 | CYSLTR1 (0.60) | CYSLTR1GPBAR1CYSLTR2ALOX5KDM4E | |
| SCHEMBL9757031 | 0.78 | CYSLTR1 (0.58) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL6091338 | 0.78 | CYSLTR1 (0.61) | CYSLTR1GPBAR1CYSLTR2ALOX5KDM4E | |
| SCHEMBL7717046 | 0.78 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |