Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757233 | 0.93 | CYSLTR1 (0.55) | CYSLTR1ALOX5GPBAR1PDE10AALOX5AP | |
| SCHEMBL9757076 | 0.91 | ALOX5 (0.59) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757124 | 0.90 | ALOX5 (0.58) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757054 | 0.84 | PDE10A (0.58) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9760846 | 0.83 | ALOX5 (0.49) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757119 | 0.83 | PDE10A (0.54) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757208 | 0.83 | CYSLTR1 (0.61) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757033 | 0.83 | PDE10A (0.54) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL6090654 | 0.79 | CYSLTR1 (0.63) | CYSLTR1ALOX5GPBAR1ALOX5AP | |
| SCHEMBL9757036 | 0.78 | CYSLTR1 (0.53) | CYSLTR1ALOX5GPBAR1PDE10ACYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |