Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.56 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.54 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757054 | 0.93 | PDE10A (0.58) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757124 | 0.92 | ALOX5 (0.58) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757031 | 0.91 | CYSLTR1 (0.58) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757036 | 0.87 | CYSLTR1 (0.53) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757119 | 0.84 | PDE10A (0.54) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757233 | 0.84 | CYSLTR1 (0.55) | ALOX5CYSLTR1GPBAR1PDE10A | |
| SCHEMBL9760846 | 0.83 | ALOX5 (0.49) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757033 | 0.83 | PDE10A (0.54) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9757716 | 0.82 | ALOX5AP (0.48) | ALOX5CYSLTR1PDE10ACYSLTR2EDNRA | |
| SCHEMBL9757258 | 0.81 | CYSLTR1 (0.60) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | claimed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | claimed |
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |