Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757147 | 0.90 | EDNRA (0.42) | NR4A2MAOBMAOARXRARXRB | |
| SCHEMBL9757647 | 0.82 | MAOB (0.34) | NR4A2MAOBMAOACYSLTR1CYSLTR2 | |
| SCHEMBL9757078 | 0.82 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757224 | 0.81 | EDNRA (0.48) | TBXAS1CYSLTR1EDNRAGPBAR1 | |
| SCHEMBL9757716 | 0.78 | ALOX5AP (0.48) | CYSLTR1CYSLTR2EDNRA | |
| SCHEMBL9757150 | 0.76 | CYSLTR1 (0.43) | TBXAS1CYSLTR1CYSLTR2EDNRA | |
| SCHEMBL9757206 | 0.74 | NR4A2 (0.42) | NR4A2MAOBMAOARXRARXRB | |
| SCHEMBL9757076 | 0.71 | ALOX5 (0.59) | CYSLTR1CYSLTR2EDNRAGPBAR1 | |
| SCHEMBL9757075 | 0.71 | ROCK1 (0.32) | MAOBMAOA | |
| SCHEMBL9757039 | 0.71 | PSMB8 (0.46) | NR4A2MAOBMAOARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | claimed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |