Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757047 | 0.78 | ALOX5 (0.42) | ALDH1A1CYP1A2KMT2AHSD17B10MAOA | |
| SCHEMBL5243894 | 0.72 | KMT2A (0.44) | NR4A2ALDH1A1MEN1KMT2ADAGLA | |
| SCHEMBL9757044 | 0.71 | ALDH1A1 (0.30) | ALDH1A1L3MBTL1HSD17B10GAA | |
| SCHEMBL4791688 | 0.69 | MAOB (0.50) | NR4A2ALDH1A1KDM4EGPR35TSHR | |
| SCHEMBL9757019 | 0.68 | PTPN1 (0.38) | ALDH1A1KDM4EL3MBTL1TSHRMEN1 | |
| SCHEMBL9757021 | 0.68 | MCL1 (0.35) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3817775 | 0.68 | AGPAT2 (0.41) | NR4A2ALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL29825622 | 0.68 | MEN1 (0.56) | ALDH1A1KDM4ECYP1A2CYP2C9GPR35 | |
| SCHEMBL3640007 | 0.68 | MEN1 (0.56) | ALDH1A1KDM4ECYP1A2CYP2C9GPR35 | |
| SCHEMBL28009417 | 0.68 | IDO1 (0.40) | NR4A2KDM4EGPR35TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |