Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757022 | 0.78 | CYSLTR1 (0.47) | — | |
| SCHEMBL24065978 | 0.66 | SMN1; SMN2 (0.60) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL24065915 | 0.66 | SMN1; SMN2 (0.60) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL17977269 | 0.65 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8260150 | 0.65 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7434354 | 0.65 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7436135 | 0.65 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7430439 | 0.65 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7434157 | 0.65 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL28535310 | 0.64 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |