Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757649 | 0.90 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757075 | 0.82 | ROCK1 (0.32) | ROCK1KMT2A | |
| SCHEMBL9757146 | 0.81 | TEC (0.37) | CYSLTR1CYSLTR2ATP4AATP4BRAB9A | |
| SCHEMBL9757150 | 0.81 | CYSLTR1 (0.43) | CYSLTR1CYSLTR2KDM4ENPC1RAB9A | |
| SCHEMBL9757192 | 0.77 | PDE10A (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757647 | 0.76 | MAOB (0.34) | CYSLTR1CYSLTR2ROCK1 | |
| SCHEMBL9757240 | 0.75 | TEC (0.38) | CYSLTR1CYSLTR2KDM4EMEN1NPC1 | |
| SCHEMBL9757187 | 0.75 | TEC (0.38) | CYSLTR1CYSLTR2KDM4EMEN1NPC1 | |
| SCHEMBL9756987 | 0.72 | PDE10A (0.49) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757078 | 0.71 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |