Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.30 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757647 | 0.90 | MAOB (0.34) | ROCK1MAOBMAOA | |
| SCHEMBL9757080 | 0.82 | CYSLTR1 (0.35) | ROCK1KMT2A | |
| SCHEMBL9757142 | 0.81 | TEC (0.37) | MAOB | |
| SCHEMBL9757147 | 0.81 | EDNRA (0.42) | CYP3A4KCNH2MAOBALOX5APMAOA | |
| SCHEMBL9757649 | 0.76 | CYSLTR1 (0.44) | — | |
| SCHEMBL9757192 | 0.76 | PDE10A (0.51) | — | |
| SCHEMBL9757175 | 0.76 | TEC (0.37) | MAOBMAOA | |
| SCHEMBL9756987 | 0.71 | PDE10A (0.49) | — | |
| SCHEMBL9757151 | 0.71 | NR4A2 (0.43) | MAOBMAOA | |
| SCHEMBL9757224 | 0.71 | EDNRA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |