Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.39 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757163 | 0.83 | CYP3A4 (0.41) | ALDH1A1SMN1; SMN2HPGDNPSR1MAPT | |
| SCHEMBL10737642 | 0.75 | HIF1A (0.54) | ALDH1A1SMN1; SMN2HPGDNPSR1KMT2A | |
| SCHEMBL9757218 | 0.75 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAPOLBMITF | |
| SCHEMBL9197360 | 0.75 | MIF (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDKMT2A | |
| SCHEMBL9488561 | 0.74 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNAPOLBMITF | |
| SCHEMBL3611112 | 0.73 | AGPAT2 (0.49) | ALDH1A1SMN1; SMN2POLBHPGDMAPT | |
| SCHEMBL11161951 | 0.73 | DAGLA (0.51) | ALDH1A1SMN1; SMN2POLBKMT2AMAPT | |
| SCHEMBL10650222 | 0.73 | NLRP3 (0.48) | ALDH1A1SMN1; SMN2LMNAHPGDKMT2A | |
| SCHEMBL10829127 | 0.73 | KDM4E (0.48) | ALDH1A1SMN1; SMN2LMNAHPGDKMT2A | |
| SCHEMBL27892480 | 0.72 | MAPT (0.43) | ALDH1A1LMNAKMT2AMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |