Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979523 | 0.81 | KDM4E (0.53) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL10222750 | 0.80 | MAPT (0.56) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL4792500 | 0.80 | MAPT (0.45) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL10239190 | 0.78 | NPC1 (0.45) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL22042872 | 0.78 | KDM4E (0.53) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL22042941 | 0.76 | KDM4E (0.51) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL24095146 | 0.76 | KDM4E (0.51) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL25488091 | 0.76 | KDM4E (0.51) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL4718226 | 0.75 | KDM4E (0.44) | MAPTKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL11167008 | 0.74 | XDH (0.55) | MAPTKDM4ENPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |