Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827466 | 0.82 | TTR (0.43) | KMT2ASMN1; SMN2ALDH1A1NPSR1NPC1 | |
| SCHEMBL10534058 | 0.80 | NPC1 (0.46) | KMT2ASMN1; SMN2ALDH1A1NPSR1NPC1 | |
| SCHEMBL9828310 | 0.80 | PDE10A (0.44) | KMT2AALDH1A1LMNAMEN1MAPT | |
| SCHEMBL4847221 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL4849365 | 0.68 | NCF1 (0.57) | KMT2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL9673655 | 0.68 | CYP1A2 (0.34) | KMT2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL6585706 | 0.67 | MAPT (0.46) | KMT2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4841795 | 0.66 | CCR1 (0.39) | KMT2ASMN1; SMN2ALDH1A1NPSR1NPC1 | |
| SCHEMBL8185499 | 0.64 | ALDH1A1 (0.59) | KMT2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL29164288 | 0.64 | SNCA (0.56) | KMT2ASMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |