Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849365 | 0.85 | NCF1 (0.57) | PDE10ANCF1ALDH1A1GFERNQO1 | |
| SCHEMBL4851483 | 0.81 | AR (0.41) | PDE10AALDH1A1CYP1A2CYP2A6MAPT | |
| SCHEMBL9757200 | 0.80 | KMT2A (0.35) | ALDH1A1GFERGAAMAPTKDM4E | |
| SCHEMBL9673655 | 0.79 | CYP1A2 (0.34) | PDE10AALDH1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL8185499 | 0.75 | ALDH1A1 (0.59) | PDE10ANCF1ALDH1A1GFERCYP1A2 | |
| SCHEMBL10534058 | 0.72 | NPC1 (0.46) | PDE10ANCF1ALDH1A1GFERNQO1 | |
| SCHEMBL7835368 | 0.72 | NCF1 (0.59) | PDE10ANCF1ALDH1A1GFERNQO1 | |
| SCHEMBL7453345 | 0.70 | PDE10A (0.61) | PDE10AALDH1A1KDM4ETDP1HDAC1 | |
| SCHEMBL203756 | 0.70 | NCF1 (0.57) | PDE10ANCF1ALDH1A1GFERNQO1 | |
| Ammonia Solution, Strong SCHEMBL28426316 | 0.70 | NCF1 (0.57) | PDE10ANCF1ALDH1A1GFERNQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |