SCHEMBL9759328

SCHEMBL9759328

CCC(CC)NC1CCc2cccc(Cl)c2C1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSEN1 P49768 1/20 0.42
PSEN2 P49810 1/20 0.42
APH1B Q8WW43 1/20 0.42
NCSTN Q92542 1/20 0.42
APH1A Q96BI3 1/20 0.42
PSENEN Q9NZ42 1/20 0.42
MTNR1A P48039 6/20 0.41
MTNR1B P49286 6/20 0.41
CYP1A2 P05177 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
DRD2 P14416 4/20 0.41
DRD3 P35462 3/20 0.41
DRD4 P21917 2/20 0.39
ADRA2A P08913 1/20 0.39
CYP2D6 P10635 1/20 0.39
ADRA2B P18089 1/20 0.39
ADRA2C P18825 1/20 0.39
ADRA1D P25100 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9190476 0.88 DRD2 (0.43) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL9189347 0.84 DRD2 (0.57) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL9758631 0.83 MTNR1A (0.41) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
SCHEMBL9758460 0.83 MTNR1A (0.41) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
SCHEMBL8891880 0.83 DRD2 (0.51) CYP1A2DRD2DRD3DRD4CYP2D6
SCHEMBL8893102 0.82 MTNR1A (0.62) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
Hydrochloric Acid SCHEMBL7935647 0.81 MTNR1A (0.60) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
SCHEMBL9759575 0.81 MTNR1A (0.43) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
SCHEMBL9187670 0.79 DRD2 (0.55) MTNR1AMTNR1BCYP1A2MAPTCYP2C9
SCHEMBL8314550 0.79 DRD2 (0.60) DRD2DRD3DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5047422-A Treating A Disorder Of The Central Nervous System, Cardiovascular System Or Intestinal Tract BAYER AKTIENGESELLSCHAFT (DE) 1991-09-10 US disclosed
US-4968679-A DISORDERS OF CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM OR INTESTINAL TRACT BAYER AKTIENGESELLSCHAFT (DE) 1990-11-06 US disclosed
US-4873262-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIIOVASCULAR SYSTEM OR INTESTINAL TRACT BAYER AKTIENGESELLSCHAFT (DE) 1989-10-10 US disclosed