Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357753 | 0.83 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL7905159 | 0.80 | BCL2L1 (0.54) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL6627142 | 0.75 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL6627140 | 0.75 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL17894510 | 0.73 | SIGMAR1 (0.61) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL4512663 | 0.73 | SIGMAR1 (0.61) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL1638724 | 0.73 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL5418295 | 0.73 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL7262779 | 0.73 | SIGMAR1 (0.53) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D | |
| SCHEMBL4573751 | 0.73 | RXRA (0.57) | ALDH1A1MEN1KMT2ASIGMAR1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272534-A2 | 8-substituted 2-aminotetralins | BAYER AG (DE) | 1988-06-29 | — | — | EP | claimed |
| US-5047422-A | Treating A Disorder Of The Central Nervous System, Cardiovascular System Or Intestinal Tract | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-10 | — | — | US | disclosed |
| US-4968679-A | DISORDERS OF CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| US-4873262-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIIOVASCULAR SYSTEM OR INTESTINAL TRACT | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0272534-A2 | 8-substituted 2-aminotetralins | BAYER AG (DE) | 1988-06-29 | — | — | EP | disclosed |