Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033202 | 0.83 | KDM4E (0.56) | CA12CA9PARP1KDM4EALDH1A1 | |
| SCHEMBL24576213 | 0.83 | MEN1 (0.64) | KDM4EALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL11069044 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL7023220 | 0.77 | LIMK1 (0.55) | CA12CA9PARP1KDM4EALDH1A1 | |
| SCHEMBL11947173 | 0.76 | MEN1 (0.60) | KDM4EALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL13780270 | 0.75 | KDM4E (0.62) | PARP1KDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9760930 | 0.74 | ADORA3 (0.56) | CA12CA9KDM4EALDH1A1RAB9A | |
| SCHEMBL11412012 | 0.73 | ATM (0.53) | PARP1KDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL8900615 | 0.73 | PDE3A (0.62) | CA12CA9PARP1KDM4EALDH1A1 | |
| SCHEMBL29152717 | 0.73 | ATM (0.57) | PARP1KDM4EALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |