Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PARG | Q86W56 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761035 | 0.80 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HPGDPOLBTDP1 | |
| SCHEMBL2115896 | 0.79 | KDM4E (0.58) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL2116094 | 0.79 | HTR3A (0.50) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL14927289 | 0.77 | ADORA3 (0.43) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL4550112 | 0.76 | HTR3A (0.47) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL14927286 | 0.75 | ADORA3 (0.41) | ADORA3ADORA2BADORA2AADORA1GLA | |
| SCHEMBL11069044 | 0.74 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HPGDRAB9AATM | |
| SCHEMBL9759896 | 0.74 | CA12 (0.51) | ALDH1A1SMN1; SMN2HPGDBRD4POLB | |
| SCHEMBL4252129 | 0.74 | KDM4E (0.64) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 | |
| SCHEMBL29897963 | 0.73 | ADORA3 (1.00) | ADORA3ADORA2BADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |