Sugi Predict

Sugi Predict / Compounds / SCHEMBL976056

SCHEMBL976056

SCHEMBL976056

Cc1nn(C)cc1C(=O)Cl

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.50
▸ ALDH1A1 P00352 5/20 0.49
▸ SMN1; SMN2 Q16637 5/20 0.49
▸ ATM Q13315 1/20 0.46
▸ NAMPT P43490 1/20 0.45
▸ MAPT P10636 2/20 0.44
▸ RAB9A P51151 5/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP2C9 P11712 2/20 0.43
▸ ALPL P05186 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ PROKR1 Q8TCW9 2/20 0.42
▸ NPC1 O15118 3/20 0.41
▸ NFKB1 P19838 1/20 0.38
▸ NFKB2 Q00653 1/20 0.38
▸ RELA Q04206 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL298523 0.81 GAA (0.51) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL1639886 0.81 GAA (0.51) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL22987577 0.80 GAA (0.59) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL2269043 0.79 KMT2A (0.42) GAASMN1; SMN2MAPTRAB9APOLB
SCHEMBL27497366 0.79 ADORA2A (0.38) GAAALDH1A1SMN1; SMN2ATMMAPT
Hydrochloric Acid SCHEMBL10666393 0.79 GAA (0.50) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL1224892 0.79 GAA (0.50) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL27708829 0.79 GAA (0.50) GAAALDH1A1SMN1; SMN2ATMNAMPT
SCHEMBL22976065 0.79 ALDH1A1 (0.51) GAAALDH1A1SMN1; SMN2NAMPTMAPT
SCHEMBL28263781 0.79 GAA (0.58) GAAALDH1A1SMN1; SMN2ATMNAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103524417-B One group of 3-methyl-4-formyl pyrazole compound QINGDAO AGRICULTURAL UNIVERSITY (CN) 2016-04-27 — — CN claimed
CN-103524417-A 3-methyl-4-formyl pyrazol compounds UNIV QINGDAO AGRICULTURAL 2014-01-22 — — CN claimed
CN-101268055-B Process for preparing 5-fluoro-1, 3-dialkyl-1H-pyrazole-4-carbonyl fluorides BAYER CROPSCIENCE AG 2011-02-16 — — CN claimed
CN-101268055-A Process for preparing 5-fluoro-1, 3-dialkyl-1H-pyrazole-4-carbonyl fluorides BAYER CROPSCIENCE AG (DE) 2008-09-17 — — CN claimed
JP-63196568-A — — None — — JP disclosed
US-20230212191-A1 SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN PRELUDE THERAPEUTICS, INCORPORATED (US) 2023-07-06 — — US disclosed
US-20230212191-A1 SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN PRELUDE THERAPEUTICS, INCORPORATED (US) 2023-07-06 — — US disclosed
US-20230212191-A1 SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN PRELUDE THERAPEUTICS, INCORPORATED (US) 2023-07-06 — — US disclosed
CN-110105346-B Optionally substituted quinoline compounds 卫材R&D管理有限公司 2023-03-10 — — CN disclosed
CN-108570018-B Amide compound and preparation method and application thereof 上海晓明检测技术服务有限公司 2022-05-13 — — CN disclosed
EP-3995495-A1 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS Eisai R&D Management Co., Ltd. (JP) 2022-05-11 — — EP disclosed
CN-108409684-B N- (2-cyclohexyloxyphenyl) amide compound and preparation method and application thereof 上海晓明检测技术服务有限公司 2022-04-12 — — CN disclosed
EP-1721899-A1 Process for the preparation of a carboxamide derivative Bayer CropScience S.A. (FR) 2006-11-15 — — EP disclosed
CN-1255384-C N-pyrazolylcarboxanilides as fungicides BAYER AGRICULTURE CORP SCIENCE (DE) 2006-05-10 — — CN disclosed
CN-1745067-A Biphenylcarboxamide compound BAYER CROPSCIENCE AG (DE) 2006-03-08 — — CN disclosed
CN-1222514-C Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesired microorganisms BAYER AG (DE) 2005-10-12 — — CN disclosed
CN-1533380-A N-pyrazolylcarboxanilides as fungicides �ݶ�ũ�����ѧ�ɷݹ�˾ 2004-09-29 — — CN disclosed
CN-1466578-A Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesired microorganisms �ݶ�ũ�����ѧ�ɷݹ�˾ 2004-01-07 — — CN disclosed
US-4792565-A Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds MITSUI TOATSU CHEMICALS, INC. (JP) 1988-12-20 — — US disclosed
JP-S63196568-A NOVEL PYRAZOLE DERIVATIVE, ITS PRODUCTION AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE MITSUI TOATSU CHEM INC 1988-08-15 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212191-A1 SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN MCL1, BCL9, BCL2L1 GAA 2916/4885ALDH1A1 849/4885SMN1; SMN2 1570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.