Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29002489 | 0.81 | ADORA2A (0.42) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL298523 | 0.81 | GAA (0.51) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL1639886 | 0.81 | GAA (0.51) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL22987577 | 0.80 | GAA (0.59) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL23366905 | 0.80 | GAA (0.47) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL22723715 | 0.80 | GAA (0.44) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL1833232 | 0.79 | ADORA2A (0.49) | GAAADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL10666393 | 0.79 | GAA (0.50) | GAAATMALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL174293 | 0.79 | ADORA2A (0.45) | GAAALDH1A1ADORA2AADORA1PROKR1 | |
| SCHEMBL976056 | 0.79 | GAA (0.50) | GAAATMALDH1A1SMN1; SMN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE INSTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-12-09 | — | — | US | claimed |
| US-20230212157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2023-07-06 | — | — | US | claimed |
| US-11597723-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2023-03-07 | — | — | US | claimed |
| CN-110461854-A | Process for preparing chiral 2, 3-dihydrothiazolo [3,2-A ] pyrimidin-4-ium compounds | BASF SE | 2019-11-15 | — | — | CN | claimed |
| CN-108117520-A | A kind of 1,3- dimethyl -1H- pyrazoles -4- amide derivatives and preparation method and application | 浙江工业大学 | 2018-06-05 | — | — | CN | claimed |
| CN-105072915-B | Synergistic composition comprising bacillus subtilis strain and biological pesticide | 巴斯夫公司 | 2018-05-01 | — | — | CN | claimed |
| CN-104507316-B | Compositions comprising biological control agents and fungicides | 拜尔农作物科学股份公司 | 2018-03-06 | — | — | CN | claimed |
| CN-105555783-B | Include the autotaxin inhibitors of heteroaromatic rings benzyl amide ring core | 诺华股份有限公司 | 2017-12-01 | — | — | CN | claimed |
| CN-107033084-A | A kind of acyl urea compound for containing 1,3 dimethyl 1H pyrrazole structures and its preparation method and application | 浙江工业大学 | 2017-08-11 | — | — | CN | claimed |
| CN-106962403-A | Include biocontrol agent and insecticide composition | 拜耳作物科学股份公司 | 2017-07-21 | — | — | CN | claimed |
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | claimed |
| EP-2536731-A1 | SUBSTITUTED SPIROINDOLINONES | F. Hoffmann-La Roche AG (CH) | 2012-12-26 | — | — | EP | claimed |
| US-8288431-B2 | Substituted spiroindolinones | HOFFMANN-LA ROCHE INC. (US) | 2012-10-16 | — | — | US | claimed |
| EP-2051983-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2009-04-29 | — | — | EP | claimed |
| WO-2008020024-A1 | NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2008-02-21 | — | — | WO | claimed |
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | claimed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | claimed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | CDK9, BMX, SBK3 | GAA 264/4885ATM 1223/4885ALDH1A1 1389/4885 |
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | GAA 352/4885ATM 1805/4885ALDH1A1 862/4885 |
| US-20230212157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCC5, ABCC1 | GAA 952/4885ATM 1636/4885ALDH1A1 1738/4885 |
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | CFTR, ABCC5, ABCC1 | GAA 952/4885ATM 1636/4885ALDH1A1 1738/4885 |
| US-11597723-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | CFTR, ABCC5, ABCC3 | GAA 970/4885ATM 1646/4885ALDH1A1 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.