Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 8/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218489 | 0.90 | HPGD (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL9196680 | 0.89 | MEN1 (0.67) | ALDH1A1KDM4EMAPK10USP2MAPT | |
| SCHEMBL2611397 | 0.85 | KDM4E (0.59) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6243745 | 0.84 | MAPT (0.60) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6243893 | 0.83 | MAPT (0.71) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6258325 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6247549 | 0.81 | MAPT (0.57) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL9760930 | 0.80 | ADORA3 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6511873 | 0.80 | HPGD (0.52) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL20988954 | 0.79 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |