Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033158 | 0.85 | LMNA (0.46) | KDM4ECA12CA9PARP1LMNA | |
| SCHEMBL7028533 | 0.81 | KDM4E (0.53) | KDM4ECA12CA9PARP1LMNA | |
| SCHEMBL7025839 | 0.80 | CA12 (0.45) | KDM4ECA12CA9PARP1LMNA | |
| SCHEMBL7034143 | 0.76 | CA12 (0.50) | KDM4ECA12CA9PARP1MAPT | |
| SCHEMBL7029630 | 0.75 | KDM4E (0.53) | KDM4ECA12CA9PARP1MAPT | |
| SCHEMBL7032078 | 0.74 | CA12 (0.40) | KDM4ECA12CA9PARP1LMNA | |
| SCHEMBL7030552 | 0.73 | PARP1 (0.44) | KDM4ECA12CA9PARP1LMNA | |
| SCHEMBL7028562 | 0.73 | CA12 (0.47) | KDM4ECA12CA9PARP1MAPT | |
| SCHEMBL20942693 | 0.72 | GAA (0.66) | KDM4ECA12CA9PARP1MAPT | |
| SCHEMBL7028337 | 0.72 | CA12 (0.50) | KDM4ECA12CA9PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |