Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760792 | 0.81 | POLB (0.51) | POLBHRH3F10MAPTMEN1 | |
| SCHEMBL5632401 | 0.81 | F10 (0.55) | SIGMAR1HRH3F10 | |
| SCHEMBL2566683 | 0.80 | SIGMAR1 (0.78) | SIGMAR1HRH3MAPTLMNA | |
| SCHEMBL1674342 | 0.79 | SIGMAR1 (0.73) | SIGMAR1POLBHRH3 | |
| SCHEMBL8681292 | 0.79 | F10 (0.51) | SIGMAR1HRH3F10 | |
| SCHEMBL7398480 | 0.79 | ITGB3 (0.53) | HRH3F10 | |
| SCHEMBL7362580 | 0.78 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL27935608 | 0.77 | SIGMAR1 (0.70) | SIGMAR1KMT2A | |
| SCHEMBL27935609 | 0.77 | SIGMAR1 (0.70) | SIGMAR1HRH3MAPT | |
| SCHEMBL2562011 | 0.77 | SIGMAR1 (0.69) | SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |