Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391369 | 0.83 | KDM4E (0.79) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL11181448 | 0.83 | KDM4E (0.79) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL11179868 | 0.79 | BRD4 (0.45) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL11177433 | 0.79 | L3MBTL1 (0.52) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL11186941 | 0.79 | BRD4 (0.45) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL11172691 | 0.79 | BRD4 (0.45) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL9720888 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL9720913 | 0.76 | NPSR1 (0.55) | KDM4EALDH1A1HPGDMEN1MAPT | |
| Alrestatin SCHEMBL31745280 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| Alrestatin SCHEMBL450743 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4369188-A | DIABETES-RELATED UROGENITAL, VISION, AND NERVOUS SYSTEM DISORDERS; ENZYME INHITITORS | AYERST, MCKENNA & HARRISON INC. (CA) | 1983-01-18 | — | — | US | claimed |
| US-4994381-A | Fermentation of Streptomyces | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0206546-B1 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4853484-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0182499-B1 | N-(6-METHOXY-5-(PERFLUOROALKYL)-1-NAPHTOLYL)-N-METYLGLYCINES AND THEIR THIONAPHTHOYL ANALOGS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1989-04-12 | — | — | EP | disclosed |
| US-4734435-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORP. (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0241144-A1 | Naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |
| US-4672058-A | N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N-methylglycinamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| US-4672059-A | ENZYME INHIBITORS; PREVENT OR TREAT DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0206546-A2 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-12-30 | — | — | EP | disclosed |
| US-4604406-A | ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-08-05 | — | — | US | disclosed |
| EP-0182499-A1 | N-(6-methoxy-5-(perfluoroalkyl)-1-naphtolyl)-N-metylglycines and their thionaphthoyl analogs | AYERST, MCKENNA AND HARRISON INC. (CA) | 1986-05-28 | — | — | EP | disclosed |
| US-4446150-A | TREATING DIABETIC COMPLICATIONS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1984-05-01 | — | — | US | disclosed |
| US-4369188-A | DIABETES-RELATED UROGENITAL, VISION, AND NERVOUS SYSTEM DISORDERS; ENZYME INHITITORS | AYERST, MCKENNA & HARRISON INC. (CA) | 1983-01-18 | — | — | US | disclosed |
| US-4369188-A | DIABETES-RELATED UROGENITAL, VISION, AND NERVOUS SYSTEM DISORDERS; ENZYME INHITITORS | AYERST, MCKENNA & HARRISON INC. (CA) | 1983-01-18 | — | — | US | disclosed |