Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.49 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6243158 | 0.80 | ERN1 (0.62) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL986274 | 0.80 | ERN1 (0.55) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL4434944 | 0.76 | LMNA (0.75) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL9639641 | 0.74 | LMNA (0.72) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL31599172 | 0.74 | LMNA (0.72) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL8371447 | 0.73 | LMNA (0.60) | ERN1TLR2TLR1TLR6LMNA | |
| Phenol SCHEMBL10718089 | 0.73 | LMNA (0.66) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL11123887 | 0.73 | ERN1 (0.62) | ERN1TLR2TLR1TLR6LMNA | |
| SCHEMBL21104414 | 0.73 | SLC6A4 (0.36) | LMNAKMT2AGAAALDH1A1HPGD | |
| SCHEMBL173014 | 0.72 | LMNA (0.55) | ERN1LMNAKMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001123-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-03-19 | — | — | US | disclosed |