Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27968266 | 0.81 | MAPT (0.46) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL9762450 | 0.76 | CYP1A2 (0.56) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL34468741 | 0.71 | ALDH1A1 (0.38) | MAPTALDH1A1SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL2252193 | 0.71 | CYP1A2 (0.61) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL2802536 | 0.70 | POLB (0.44) | MAPTALDH1A1SMN1; SMN2POLBTDP1 | |
| SCHEMBL3095395 | 0.70 | MAPT (0.78) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL361410 | 0.70 | POLB (0.57) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL12218095 | 0.69 | MAPT (0.68) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL9761085 | 0.68 | MAPT (0.40) | MAPTALDH1A1CYP1A2CYP2C9NPSR1 | |
| SCHEMBL9059478 | 0.67 | CTSB (0.56) | MAPTALDH1A1CYP1A2CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026694-A | Antitumor agents | THE BRITISH COLUMBIA CANCER FOUNDATION (CA) | 1991-06-25 | — | — | US | disclosed |