Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9762432 | 1.00 | KCNH2 (0.49) | KCNH2CHRM1HRH1CYP2D6CCNT1 | |
| SCHEMBL9761330 | 1.00 | KCNH2 (0.49) | KCNH2CHRM1HRH1CYP2D6CCNT1 | |
| SCHEMBL9762424 | 0.84 | AVPR1A (0.47) | KCNH2OPRD1OPRK1 | |
| SCHEMBL27757638 | 0.84 | KCNH2 (0.48) | KCNH2CYP2D6OPRD1OPRK1 | |
| SCHEMBL28019128 | 0.76 | HRH3 (0.42) | KCNH2 | |
| SCHEMBL9761678 | 0.75 | KCNH2 (0.55) | KCNH2CHRM1HRH1CYP2D6LSS | |
| SCHEMBL9762594 | 0.75 | KCNH2 (0.55) | KCNH2CHRM1HRH1CYP2D6LSS | |
| SCHEMBL9762662 | 0.75 | KCNH2 (0.55) | KCNH2CHRM1HRH1CYP2D6LSS | |
| SCHEMBL10436396 | 0.73 | KCNH2 (0.43) | KCNH2CHRM1HRH1 | |
| SCHEMBL10436395 | 0.73 | KCNH2 (0.43) | KCNH2CHRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |
| EP-0397614-A2 | Pharmacologically active piperdinylimidazopyridines | DOMPE' FARMACEUTICI S.p.A. (IT) | 1990-11-14 | — | — | EP | disclosed |