Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27855301 | 0.74 | ADRA2B (0.46) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL135869 | 0.74 | ADRA2B (0.62) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL30062527 | 0.73 | ALDH1A1 (0.61) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL9762895 | 0.73 | DNM1 (0.54) | MAOBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9762677 | 0.73 | DNM1 (0.54) | MAOBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9761751 | 0.73 | DNM1 (0.54) | MAOBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL154098 | 0.73 | TSHR (0.46) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL27230567 | 0.72 | ADRA2B (0.60) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL148026 | 0.72 | ADRA2B (0.44) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 | |
| SCHEMBL150754 | 0.72 | MAOB (0.47) | ADRA2BADRA2CADRA1AOPRK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990683-A | Process for preparing 3-pyrrolidinols | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-02-05 | — | — | US | disclosed |
| EP-0269258-A2 | Process for the preparation of a pyrrolidinol compound | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |