Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527012 | 0.89 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL9528871 | 0.88 | BPTF (0.47) | HTR1AADRA1DADRA1AADRA1BHTR7 | |
| SCHEMBL9528648 | 0.88 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9526736 | 0.86 | ADRA1A (0.62) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL9526933 | 0.85 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL27263870 | 0.83 | DRD4 (0.50) | HTR1AADRA1AADRA1BADRA2AADRA2C | |
| SCHEMBL9527540 | 0.83 | ADRA1A (0.54) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL9531782 | 0.82 | HTR1A (0.53) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL9526823 | 0.81 | HTR1A (0.64) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL9527725 | 0.80 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |