Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763518 | 0.88 | HTR1A (0.52) | ADRA1AADRA1DADRA1BHTR1AHTR7 | |
| SCHEMBL9531556 | 0.85 | ADRA1A (0.53) | BPTFADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL27263870 | 0.80 | DRD4 (0.50) | BPTFADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9526613 | 0.80 | ADRA1A (0.52) | BPTFADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9527012 | 0.77 | HTR1A (0.56) | ADRA1AADRA1DADRA1BHTR1AHTR7 | |
| SCHEMBL9528648 | 0.76 | HTR1A (0.56) | ADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9528841 | 0.75 | ADRA1B (0.55) | BPTFADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9528184 | 0.75 | ADRA1A (0.58) | BPTFADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9527111 | 0.74 | BPTF (0.51) | BPTFADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9527047 | 0.73 | BRD4 (0.57) | BPTFADRA1AADRA1DADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |