Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 9/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183190 | 0.82 | METAP2 (0.49) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL6746143 | 0.78 | NPC1 (0.55) | — | |
| SCHEMBL5512822 | 0.77 | — | — | |
| SCHEMBL1170747 | 0.76 | METAP1 (0.72) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL12833537 | 0.75 | PDE5A (0.55) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL7456052 | 0.75 | PDE5A (0.66) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL2175033 | 0.74 | CDK1 (0.69) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL30802417 | 0.74 | CDK1 (0.69) | PDE5AAURKAMETAP1METAP2PDE4A | |
| SCHEMBL9581 | 0.74 | — | — | |
| SCHEMBL3464753 | 0.73 | KDM4E (0.41) | AURKAMETAP1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066652-A | ANTIULCER AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1991-11-19 | — | — | US | disclosed |