Bromide

Bromide

SCHEMBL9763700

Br.Br.O=C(C1CCCNC1)N1CCN(C(=O)C2CCCNC2)CC1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A1 P30531 2/20 0.57
TSHR P16473 2/20 0.57
LMNA P02545 2/20 0.57
SLC6A11 P48066 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
SLC6A13 Q9NSD5 1/20 0.57
ALDH1A1 P00352 2/20 0.55
KMT2A Q03164 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MAPT P10636 1/20 0.55
ATM Q13315 1/20 0.55
CYP2D6 P10635 1/20 0.55
CHRNB2 P17787 1/20 0.52
CHRNA3 P32297 1/20 0.52
CHRNA4 P43681 1/20 0.52
CHRNB3 Q05901 1/20 0.52
CHRNA6 Q15825 1/20 0.52
NOS2 P35228 1/20 0.46
PARP1 P09874 1/20 0.46
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9763185 0.98 SLC6A1 (0.59) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL16584420 0.92 SLC6A1 (0.57) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL20811833 0.92 SLC6A1 (0.57) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL2655363 0.92 SLC6A1 (0.57) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
Hydrochloric Acid SCHEMBL16584136 0.91 SLC6A1 (0.55) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
Hydrochloric Acid SCHEMBL15321278 0.91 SLC6A1 (0.55) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL18390874 0.91 CHRNB2 (0.66) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL319228 0.91 HPGD (0.59) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL24324162 0.90 LMNA (0.58) SLC6A1TSHRLMNASLC6A11SMN1; SMN2
SCHEMBL3006073 0.90 LMNA (0.58) SLC6A1TSHRLMNASLC6A11SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4994462-A N,N-Bis(nipecotyl)piperazines RESEARCH CORPORATION (US) 1991-02-19 US claimed