Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9005712 | 1.00 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL9005760 | 0.86 | BRD4 (0.40) | SMN1; SMN2KDM1ABRD4HTTNPC1 | |
| SCHEMBL9654387 | 0.86 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL4370199 | 0.81 | KEAP1 (0.52) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL10100499 | 0.78 | KEAP1 (0.55) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL10858563 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL9602078 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KIF11CA1CA2 | |
| SCHEMBL698855 | 0.76 | KEAP1 (0.70) | ALDH1A1SMN1; SMN2KEAP1POLBKIF11 | |
| SCHEMBL8867745 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL11466281 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344197-B1 | NOVEL N-1 SUBSTITUTED BETA-LACTAMS AS ANTIBIOTICS | THE UPJOHN COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| US-5015737-A | Antibiotics, bactericides | THE UPJOHN COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| US-5006650-A | Antibiocides | THE UPJOHN COMPANY (US) | 1991-04-09 | — | — | US | disclosed |
| US-5001235-A | Antibiotic beta-lactams containing a pyridone carboxylic acid or acid derivative | THE UPJOHN COMPANY (US) | 1991-03-19 | — | — | US | disclosed |
| US-4975538-A | MICROBIOCIDES AND BETA-LACTAMASE INHIBITORS | THE UPJOHN COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0352269-A1 | ANTIBIOTIC SULFONYLAMINOCARBONYL ACTIVATED $g(b)-LACTAMS | THE UPJOHN COMPANY (US) | 1990-01-31 | — | — | EP | disclosed |
| EP-0344197-A1 | NOVEL N-1 SUBSTITUTED BETA-LACTAMS AS ANTIBIOTICS. | UPJOHN CO (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4883869-A | BACTERICIDES, ANTIBIOTICS | THE UPJOHN COMPANY (US) | 1989-11-28 | — | — | US | disclosed |
| US-4837318-A | Carbonate substituted monobactams as antibiotics | THE UPJOHN COMPANY (US) | 1989-06-06 | — | — | US | disclosed |
| WO-1988006588-A1 | ANTIBIOTIC SULFONYLAMINOCARBONYL ACTIVATED beta-LACTAMS | THE UPJOHN COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |
| WO-1988006156-A1 | NOVEL N-1 SUBSTITUTED beta-LACTAMS AS ANTIBIOTICS | THE UPJOHN COMPANY (US) | 1988-08-25 | — | — | WO | disclosed |