Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763680 | 0.89 | TDP1 (0.42) | TDP1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9764370 | 0.83 | TDP1 (0.45) | TDP1KCNH2ALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL8552668 | 0.79 | TDP1 (0.58) | TDP1KCNH2ALDH1A1SMN1; SMN2HTR2A | |
| SCHEMBL9763396 | 0.77 | TDP1 (0.43) | TDP1LTA4HEPHX2 | |
| SCHEMBL15141450 | 0.76 | TDP1 (0.49) | TDP1ALDH1A1SMN1; SMN2CA1CA2 | |
| SCHEMBL1180141 | 0.75 | TDP1 (0.58) | TDP1ALDH1A1CA1CA2CA9 | |
| Di(Hydroxyethyl)Ether SCHEMBL16085977 | 0.75 | TDP1 (0.58) | TDP1ALDH1A1CA1CA2CA9 | |
| SCHEMBL9763224 | 0.75 | TDP1 (0.44) | TDP1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9995347 | 0.74 | TDP1 (0.56) | TDP1ALDH1A1SMN1; SMN2CA1CA2 | |
| SCHEMBL4185009 | 0.74 | TDP1 (0.56) | TDP1ALDH1A1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |