Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | HTR1D | P28221 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558613 | 0.86 | HTR6 (0.65) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL6631360 | 0.84 | HTR6 (0.60) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL8820109 | 0.82 | HSD17B10 (0.56) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL9764510 | 0.80 | SLC6A4 (0.65) | — | |
| SCHEMBL7487134 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL7487825 | 0.78 | HTR6 (0.51) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL24670856 | 0.78 | CCNT1 (0.66) | HTR2CHTR6CCNT1CDK9 | |
| SCHEMBL29961028 | 0.78 | CCNT1 (0.66) | HTR2CHTR6CCNT1CDK9 | |
| SCHEMBL3836149 | 0.77 | HTR6 (0.67) | KDM4EALDH1A1HTR2CHSD17B10HTR1D | |
| SCHEMBL6631651 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1HTR2CHSD17B10HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066660-A | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |