Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HTR1D | P28221 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.54 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764393 | 0.86 | KDM4E (0.59) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL6631360 | 0.84 | HTR6 (0.60) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL9764585 | 0.80 | SLC6A4 (0.67) | — | |
| Ru-24969 SCHEMBL29390076 | 0.79 | HTR6 (1.00) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL31700695 | 0.79 | CCNT1 (0.42) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| Ru-24969 SCHEMBL2359264 | 0.79 | HTR6 (1.00) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL15787045 | 0.79 | IMPDH2 (0.58) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| Ru-24969 SCHEMBL29550112 | 0.78 | HTR6 (0.81) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL8820109 | 0.78 | HSD17B10 (0.56) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL3836149 | 0.77 | HTR6 (0.67) | HTR6KDM4EALDH1A1MAPTHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |