Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477755 | 1.00 | SIGMAR1 (0.69) | SIGMAR1MAOACHRM2GAAMAPT | |
| Hydrochloric Acid SCHEMBL9258435 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL456614 | 0.93 | SIGMAR1 (0.80) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL9666404 | 0.93 | SIGMAR1 (0.74) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL10952736 | 0.93 | MAOA (0.77) | SIGMAR1MAOACHRM2GAAMAPT | |
| Bromide SCHEMBL9578037 | 0.92 | SIGMAR1 (0.72) | SIGMAR1MAOACHRM2GAAMAPT | |
| Bromide SCHEMBL7121198 | 0.92 | SIGMAR1 (0.77) | SIGMAR1MAOACHRM2GAAMAPT | |
| Hydrochloric Acid SCHEMBL9260556 | 0.92 | SIGMAR1 (0.72) | SIGMAR1MAOACHRM2GAAMAPT | |
| Hydrochloric Acid SCHEMBL454214 | 0.92 | SIGMAR1 (0.77) | SIGMAR1MAOACHRM2GAAMAPT | |
| Hydrochloric Acid SCHEMBL9257562 | 0.92 | SIGMAR1 (0.77) | SIGMAR1MAOACHRM2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4959381-A | ADRENERGIC STIMULANTS | GLAXO GROUP LIMITED (GB) | 1990-09-25 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0278727-A2 | 1-(4-Amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease | GLAXO GROUP LIMITED (GB) | 1988-08-17 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |